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RULE NUMBER ONE ! EXPERIMENT!!!
But here are some starting points...
STARTING POINT - MOST INDOOR SITUATIONS
In most indoor situations, shoot with the dome on, pointed straight up...
EXAMPLE IMAGE - ISO 400 1/90sec F1.4
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 Introduction  Mounting  Settings  Indoors  High Ceilings  Outdoors  F.A.Q.  Gary's Blog  Reference Card